Clem Ohameze was born in Port Harcourt, Rivers, Nigeria. He attended Holy Family College / Baptist High School; Institute of Management Technology, Enugu, Nigeria where he secured an Ordinary National Diploma in Mass Communication; and University of Port Harcourt where he graduated with a BSc in Sociology and Anthropology in 1984. He also studied at the Buckingham University, London in 2010 and obtained a Masters in Preventive and Social Medicine.
Ohameze is a member of the Actors Guild of Nigeria. He briefly broke away from acting between 2006 and 2010 to pursue other interests including politics. He has since returned to his movie career after the break. In 2010, Ohameze starred in the award-winning movie Ije: The Journey alongside Genevieve Nnaji and Omotola Jalade Ekeinde.